Synthesis, characterization and photocatalytic application of TiO2 nanosized particles / by Dongliang Liao.

In this thesis, effects of surfactant composition and concentration on shape, size, zeta potential, and photocatalytic activity of TiO2 nanosized particles are reported. Spherical, cubic, rod, ellipse and leaf-like shaped TiO2 nanosized particles were obtained with the addition of different surfactants in various composition and concentrations during preparation. The results show that the shape and size of the TiO 2 nanosized particles depend on not only surfactant composition but also surfactant concentration. The pH dependence of zeta potential of TiO2 nanosized particles was studied. A unique finding is that TiO2 nanosized particles shaped by sodium dodecyl sulfate (SDS) have two isoelectric points (IEPs), while other shape-controlled TiO2 nanosized particles have only one IEP. At neutral pH, shape-and size-controlled TiO2 nanosized particles have a more negative zeta potential than TiO2 nanosized particles obtained without the addition of surfactants during synthesis and commercial anatase TiO2 nanosized particles Degussa P-25. Different zeta potential values are observed for TiO2 nanosized particles obtained with the addition of different surfactants during preparation. The addition of SDS in TiO2 nanoparticle suspensions causes a shift of the lEPs to lower pH values. Photocatalytic activity of prepared TiO2 nanosized particles was evaluated in fixed film batch reactors. TiO2 nanosized particles with different shapes and sizes showed different activities in photocatalytic decomposition of methyl orange (MO) and phenol. Photocatalytic activity of shape- and size-controlled TiO2 nanosized particles is higher than those without the use of surfactant and P-25. Photocatalytic decomposition of phenol and MO follows the first order reaction kinetics. The analysis of reaction rate constants and adsorption equilibrium constants shows that the shape is more important than the size in determining the photocatalytic activity of shape- and size-controlled TiO2 nano sized particles. A comparison of the reaction rates indicated that TiO2 nanorods have higher photocatalytic activities than spherical and cubic TiO2 nanosized particles. All these results indicate that shape, size, zeta potential and photocatalytic activity of TiO2 nanosized particles can be manipulated with the introduction of surfactants (types and concentrations) during preparation

Cognitive Representation Learning of Self-Media Online Article Quality

The automatic quality assessment of self-media online articles is an urgent and new issue, which is of great value to the online recommendation and search. Different from traditional and well-formed articles, self-media online articles are mainly created by users, which have the appearance characteristics of different text levels and multi-modal hybrid editing, along with the potential characteristics of diverse content, different styles, large semantic spans and good interactive experience requirements. To solve these challenges, we establish a joint model CoQAN in combination with the layout organization, writing characteristics and text semantics, designing different representation learning subnetworks, especially for the feature learning process and interactive reading habits on mobile terminals. It is more consistent with the cognitive style of expressing an expert's evaluation of articles. We have also constructed a large scale real-world assessment dataset. Extensive experimental results show that the proposed framework significantly outperforms state-of-the-art methods, and effectively learns and integrates different factors of the online article quality assessment.Comment: Accepted at the Proceedings of the 28th ACM International Conference on Multimedi

Epithelial Neoplasia Coincides with Exacerbated Injury and Fibrotic Response in the Lungs of \u3cem\u3eGprc5a\u3c/em\u3e-Knockout Mice Following Silica Exposure

Exposure to crystalline silica is suggested to increase the risk for a variety of lung diseases, including fibrosis and lung cancer. However, epidemiological evidences for the exposure-risk relationship are ambiguous and conflicting, and experimental study from a reliable animal model to explore the relationship is lacking. We reasoned that a mouse model that is sensitive to both lung injury and tumorigenesis would be appropriate to evaluate the exposure-risk relationship. Previously, we showed that, Gprc5a-/- mice are susceptible to both lung tumorigenesis and endotoxin-induced acute lung injury. In this study, we investigated the biological consequences in Gprc5a-/- mouse model following silica exposure. Intra-tracheal administration of fine silica particles in Gprc5a-/- mice resulted in more severe lung injury and pulmonary inflammation than in wild-type mice. Moreover, an enhanced fibrogenic response, including EMT-like characteristics, was induced in the lungs of Gprc5a-/- mice compared to those from wild-type ones. Importantly, increased hyperplasia or neoplasia coincided with silica-induced tissue injury and fibrogenic response in lungs from Gprc5a-/- mice. Consistently, expression of MMP9, TGFβ1 and EGFR was significantly increased in lungs from silica-treated Gprc5a-/- mice compared to those untreated or wild-type ones. These results suggest that, the process of tissue repair coincides with tissue damages; whereas persistent tissue damages leads to abnormal repair or neoplasia. Thus, silica-induced pulmonary inflammation and injury contribute to increased neoplasia development in lungs from Gprc5a-/- mouse model

Origami-inspired soft twisting actuator

Soft actuators have shown great advantages in compliance and morphology matched for manipulation of delicate objects and inspection in a confined space. There is an unmet need for a soft actuator that can provide torsional motion to e.g. enlarge working space and increase degrees of freedom. Towards this goal, we present origami-inspired soft pneumatic actuators (OSPAs) made from silicone. The prototype can output a rotation of more than one revolution (up to 435{\deg}), more significant than its counterparts. Its rotation ratio (=rotation angle/ aspect ratio) is more than 136{\deg}, about twice the largest one in other literature. We describe the design and fabrication method, build the analytical model and simulation model, and analyze and optimize the parameters. Finally, we demonstrate the potentially extensive utility of the OSPAs through their integration into a gripper capable of simultaneously grasping and lifting fragile or flat objects, a versatile robot arm capable of picking and placing items at the right angle with the twisting actuators, and a soft snake robot capable of changing attitude and directions by torsion of the twisting actuators.Comment: 9 figures. Soft Robotics (2022

Make Your Brief Stroke Real and Stereoscopic: 3D-Aware Simplified Sketch to Portrait Generation

Creating the photo-realistic version of people sketched portraits is useful to various entertainment purposes. Existing studies only generate portraits in the 2D plane with fixed views, making the results less vivid. In this paper, we present Stereoscopic Simplified Sketch-to-Portrait (SSSP), which explores the possibility of creating Stereoscopic 3D-aware portraits from simple contour sketches by involving 3D generative models. Our key insight is to design sketch-aware constraints that can fully exploit the prior knowledge of a tri-plane-based 3D-aware generative model. Specifically, our designed region-aware volume rendering strategy and global consistency constraint further enhance detail correspondences during sketch encoding. Moreover, in order to facilitate the usage of layman users, we propose a Contour-to-Sketch module with vector quantized representations, so that easily drawn contours can directly guide the generation of 3D portraits. Extensive comparisons show that our method generates high-quality results that match the sketch. Our usability study verifies that our system is greatly preferred by user.Comment: Project Page on https://hangz-nju-cuhk.github.io

G9a Is Essential for EMT-Mediated Metastasis and Maintenance of Cancer Stem Cell-Like Characters in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is a particularly aggressive cancer with poor prognosis, largely due to lymph node metastasis and local recurrence. Emerging evidence suggests that epithelial-to-mesenchymal transition (EMT) is important for cancer metastasis, and correlated with increased cancer stem cells (CSCs) characteristics. However, the mechanisms underlying metastasis to lymph nodes in HNSCC is poorly defined. In this study, we show that E-cadherin repression correlates with cancer metastasis and poor prognosis in HNSCC. We found that G9a, a histone methyltransferase, interacts with Snail and mediates Snail-induced transcriptional repression of E-cadherin and EMT, through methylation of histone H3 lysine-9 (H3K9). Moreover, G9a is required for both lymph node-related metastasis and TGF-β-induced EMT in HNSCC cells since knockdown of G9a reversed EMT, inhibited cell migration and tumorsphere formation, and suppressed the expression of CSC markers. Our study demonstrates that the G9a protein is essential for the induction of EMT and CSC-like properties in HNSCC. Thus, targeting the G9a-Snail axis may represent a novel strategy for treatment of metastatic HNSCC

Autocrine Epiregulin Activates EGFR Pathway for Lung Metastasis Via EMT in Salivary Adenoid Cystic Carcinoma

Salivary adenoid cystic carcinoma (SACC) is characterized by invasive local growth and a high incidence of lung metastasis. Patients with lung metastasis have a poor prognosis. Treatment of metastatic SACC has been unsuccessful, largely due to a lack of specific targets for the metastatic cells. In this study, we showed that epidermal growth factor receptors (EGFR) were constitutively activated in metastatic lung subtypes of SACC cells, and that this activation was induced by autocrine expression of epiregulin (EREG), a ligand of EGFR. Autocrine EREG expression was increased in metastatic SACC-LM cells compared to that in non-metastatic parental SACC cells. Importantly, EREG-neutralizing antibody, but not normal IgG, blocked the autocrine EREG-induced EGFR phosphorylation and the migration of SACC cells, suggesting that EREG-induced EGFR activation is essential for induction of cell migration and invasion by SACC cells. Moreover, EREG-activated EGFR stabilized Snail and Slug, which promoted EMT and metastatic features in SACC cells. Of note, targeting EGFR with inhibitors significantly suppressed both the motility of SACC cells in vitro and lung metastasis in vivo. Finally, elevated EREG expression showed a strong correlation with poor prognosis in head and neck cancer. Thus, targeting the EREG-EGFR-Snail/Slug axis represents a novel strategy for the treatment of metastatic SACC even no genetic EGFR mutation

The United States COVID-19 Forecast Hub dataset

Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an academic research lab at the University of Massachusetts Amherst to create the US COVID-19 Forecast Hub. Launched in April 2020, the Forecast Hub is a dataset with point and probabilistic forecasts of incident cases, incident hospitalizations, incident deaths, and cumulative deaths due to COVID-19 at county, state, and national, levels in the United States. Included forecasts represent a variety of modeling approaches, data sources, and assumptions regarding the spread of COVID-19. The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regarding COVID-19 mitigation. These open-source data are available via download from GitHub, through an online API, and through R packages